The present work describes Q-absorbance spectrophotometric method for simultaneous estimation of tapentadol and thiocolchicoside in tablet dosage form. It employs development of Q-absorption ratio method using two wavelengths 272 nm of tapentadol and 265 nm an Iso-bestic point of both the drug. The method obeys beer’s law in the employed concentration range of 5-35 μg/ml for thiocolchicoside and 50-250 μg/ml for tapentadol at their respective wavelengths. Results of analysis were validated statistically and by recovery studies.
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